Toxicology · Molecular biology
Ardie Barry Sailis
I study how cells handle chemical stress, and what happens when they cannot.
Two research tracks connect environmental exposure to cellular recovery: how vaping affects male reproductive health, and how cells bring stress signals to an end.
Vaping and male reproductive health
Smokers, vapers and dual users compared, so the aerosol itself is the variable.
Cellular signaling circuits
Five papers treating pathways as control systems that must also resolve, not switches.
Researcher
Toxicology and molecular biology
Petaling Jaya, Selangor, Malaysia
ORCID 0009-0009-8994-2793 Scopus ID 60192026900
The unfolded protein response as a proteotoxic stress-resolution circuit
A framework in which environmental toxicants act as proteotoxic inputs, IRE1α, PERK and ATF6 decode ER stress into immune outcomes, and failed resolution can shift immune and barrier cells into persistent dysfunction.
Report recovery kinetics, branch-specific signaling and functional immune output, so incomplete recovery rather than peak activation becomes the variable.
Both tracks, side by side
The doctoral study and the circuit framework, with the questions each one is built to answer.
Find this work useful?
Help keep my independent research and open projects going.
Latest News
- Oct 2026 New review in Chemico-Biological Interactions proposing the unfolded protein response as a proteotoxic stress-resolution circuit in environmental immunotoxicity.
- Oct 2026 New review in Progress in Biophysics and Molecular Biology proposing YAP/TAZ as a mechanochemical signal-resolution circuit.
- Oct 2026 Presented my PhD thesis seminar.
- Aug 2026 New paper in Journal of Applied Toxicology on how metal-containing nanoparticles from e-cigarettes may harm male reproduction through mitochondria.
- Aug 2026 New paper in Gene Reports on transcriptional condensates as kinetic filters for gene expression.
For academic correspondence, use the Contact page. Updated 3 November 2026.